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1 The incretin effect was termed when researchers noted that individuals had a greater secretion of insulin following an oral glucose challenge as opposed to IV glucose administration

Executive Vice President of R&D James Bradner doubled down on this position, when an analyst brought up that more convenient schedules could come at the cost of weaker weight loss outcomes

Real-world data from healthcare databases have occasionally shown small increases in pancreatitis incidence, though these findings may reflect confounding factors such as obesity severity, rapid weight loss, or pre-existing pancreatic disease

Rising prevalence of diabetes The global prevalence of diabetes has been steadily rising

Jessica Duncan, an obesity certified MD and Chief Medical Officer at Ivim Health

Clinical implication Considering the potential for gastric food retention and aspiration risks associated with surgical or endoscopic interventions, the American Society of Anesthesiologists recommends the discontinuation of short-acting GLP-1 RAs one day and long-acting formulations at least 1 week before surgical procedures [27]