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GLP-1 Weight-Loss Drugs and Breast Cancer: What We Know So Far If youre living with breast cancer or have a history of it, youve probably heard a lot about GLP-1 agonistsoften just called GLP-1 drugsfor weight loss and diabetes

8.0%, hazard ratio [HR]: 0.80, 95% CI 0.72, 0.90)

Pharmacologically, only short-acting GLP-1RAs demonstrate a marked reduction in gastric emptying (156), while chronic activation of GLP-1R results in a waning effect on gastric emptying due to tachyphylaxis

One of those medications, Wegovy, is also FDA-approved for the treatment of cardiovascular disease

The REWIND trial mainly assessed the cardiovascular outcomes of dulaglutide over up to 8 years

However, a retrospective study by Richardson et al