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This model better reconciles with our results using SANA, where Ckm is systematically upregulated, and does not necessarily antagonize the experimental evidence already published 19,23,37

This suggests that metformin-induced glucose reduction is dependent on SGLT1 expression (Zubiaga et al., 2023)

Expert takeaway Karen Berger, Pharm

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This improvement in insulin sensitivity is one reason semaglutide produces weight loss even in people without diabetes

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