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Managing expectations in the titration phase It is important to understand that the full therapeutic effect is not achieved at the 2 mg starting dose

doi: 10.1172/JCI105714

For example, studies have been looking at the use of GLP-1s for reducing the risk of cardiovascular disease and chronic kidney disease, treatment of nonalcoholic fatty liver disease and Now, two new studies recently presented at the 2026 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS) offer insights on how GLP-1 medications might influence musculoskeletal health, both positively and negatively

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

Tirzepatide is a dual-agonist peptide researched for its interaction with both GLP-1 receptors and GIP receptors