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In the United States, the Food and Drug Administration warned about selling unapproved semaglutide

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They made 1 purchase worth up to $15,000 on 12/29 and 1 sale worth up to $15,000 on 02/13

The petitioner sought urgent measures such as suspension of approvals for non-diabetic use, a ban on off-label promotion, and a pharmacovigilance mechanism

The mechanisms likely involve both the hormonal disruption of rapid fat loss (fat tissue helps regulate oestrogen and testosterone) and the direct effects of GLP-1 receptor activation on dopamine-mediated sexual motivation