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Ondansetron (Zofran), a 5-HT3 receptor antagonist, effectively reduces nausea and is commonly prescribed off-label for GLP-1 side effects

Eric Topol, a research methods expert and director of Scripps Research Translational Institute

Paradoxically, a separate study published in the same journal, around the same time, analyzed body-contouring outcomes in GLP-1 patients, and did not find an increased rate of post-op complications

These providers specialize in obesity medicine and are trained on GLP-1 therapy protocols

The improved blood sugar stability may also contribute, as overnight glucose fluctuations can interrupt sleep cycles

By day fourteen, drug levels fall to roughly 25% of peak concentration