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Common gastrointestinal side effects include: Nausea and vomiting (affecting 1540% of patients, depending on the specific medication and dose) [13] [16] Diarrhoea (reported in 1030% of patients) Constipation (affecting 1020% of patients) Abdominal pain and discomfort Reduced appetite and early satiety Dyspepsia and gastro-oesophageal reflux symptoms These effects are generally dose-dependent and tend to improve over time as the body adjusts to the medication

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In contrast, of the two melatonin receptors tested, MTNR1A showed strong performance with low background activity and robust SEAP induction upon melatonin stimulation (Fig

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