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In vivo evidence of the role of GLP-1/GLP-1R is from Glp-1r / mice, which exhibited an increased number of osteoclasts accompanied by greater bone resorption activity and increased expression of osteoclast-related genes

No significant differences were observed in subjects with weight loss surgeries, arthritis, or retinopathy

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While genetics do not predict exact medication response, they can provide context for why consistent dosing and proper storage mattergenetic variations in receptor sensitivity make reliable, stable dosing increasingly important for achieving therapeutic outcomes

Furthermore, leptin receptor-deficient mice, a mouse model of obesity and diabetes, and people with endogenous glucagon deficiency (pancreatectomised individuals) treated with glucagon antisense oligonucleotide have increased hepatic fat [52, 53]

"The current cost is too expensive for the general population," Dr