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The MOMENTUM Phase II obesity trial demonstrated compelling weight loss and a favorable safety profile

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Research participants using GLP-1 therapy often experience reductions in total cholesterol, LDL (bad) cholesterol, and triglycerides within weeks to months of starting treatment

Neuroprotective effects of GLP-1RAs in AD, PD, and other in vivo disease models Effects on wild type and diabetes in vivo models The neuroprotection of GLP-1RAs in in vivo models is underpinned by the ability of GLP-1RAs to cross the bloodbrain barrier (BBB) and by the presence of GLP-1 receptors in the brain

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Patients still gained weight on both treatments but had statistically significant less weight gain on olanzapine-samidorphan versus olanzapine (6.9 versus 10.7 lb), especially in patients with lower BMI