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These systems often use biocompatible polymers like polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), sodium alginate, or gelatin, and may include functional components such as egg-derived proteins or silk fibroin to mimic biological properties and enhance mechanical strength and drug stability [40]

Thirdly, the COVID-19 pandemic significantly impacted the study, with the majority of participants either randomised just before the pandemic or reaching the critical 6 month and 12-month trial milestones during the pandemic

greater ease and scalability of manufacturing

The primary advantages of oral formulations are convenience and needle avoidance, not faster onset

doi: 10.3389/fendo.2022.891297 127 ChangZPDengGFShaoYYXuDZhaoYNSunYFet al

Berkovic MC, Virovic-Jukic L, Bilic-Curcic I, Mrzljak A
