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10.1093/annonc/mdv027 41 FujiwaraM.IzuishiK.SanoT.HossainM

Protein targets and practical strategies when appetite is suppressed Protein is the primary lever

There is no established pharmacologic mechanism by which GLP-1 receptor agonism would directly cause musculoskeletal pain

Hence, GLP-1RAs can be utilized as an adjunct alongside metformin as a first-line treatment for type 2 DM or, in specific cases, as a preferred therapeutic agent when additional benefits for cardiovascular or renal protection are required [84]

DOI:10.1016/s0014-2999(96)00795-9 [2] Elahi D, et al

Liraglutide , marketed under the brand name Saxenda, is one such treatment approved for chronic weight management in individuals with a body mass index (BMI) of 30 or higher, or those with a BMI of 27 or higher who have at least one weight-related condition