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Natriuresis and volume effects may occur through GLP-1 receptor activation

When the stomach empties more slowly, this can lead to: A sensation of abdominal fullness or distension Altered bowel motility patterns affecting the transit of intestinal contents Potential changes in digestive processes Possible gas accumulation in the digestive tract It is important to note that there is no official indication for GLP-1 medications as a treatment for bloating

V Wellness titrates the medication gradually over 16-20 weeks to reach full therapeutic dosing while minimizing gastrointestinal side effects

Adams TD, Davidson LE, Litwin SE, et al

It is essential to recognize that most current evidence comes from preclinical models or small human studies with methodological limitations

however, no clinical correlates have yet been shown in humans