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In addition, the gut-derived metabolite imidazole propionate has been shown to drive -synuclein pathology in preclinical and patient-derived PD models, providing a direct link between dysbiosis and -synuclein aggregation (103)

Secher, Jelsing, Baqueror)

Semaglutide (Wegovy) and tirzepatide (Zepbound) have demonstrated significant average weight loss14.9% and 20.9% of body weight at approximately one year, respectively

These are important processes for metabolic health and energy balance

[53] The five used in efficacy evaluation included 6,263 adult participants with type 2 diabetes

Fat distribution, body mass index and blood pressure in 22,090 men and women in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) study