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Key findings, including the potential protective effects of GLP-1RAs on schizophrenia, anxiety disorders, and autism, were consistently observed across multiple independent datasets, reinforcing the robustness and reproducibility of the results

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In addition, with the increased interest of researchers in multi-omics studies, transcriptomic and metabolomic studies on the gut microbiota have increased

The success with GLP-1 drugs has also prompted researchers to start investigating in detail the physiology of GLP-1 in the gut and the brain

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Bariatric surgery has helped improve our knowledge of the mechanisms underlying gutpancreas interactions and may enable development of effective dietary or pharmacological strategies in the management of diabetes