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As a dual GLP-1/glucagon receptor agonist, mazdutide attacks fat through two pathways instead of one, boosting both appetite suppression and metabolic rate simultaneously

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65 In a meta-analysis by He et al, which included 76 RCTs covering more than 100,000 overweight or obese individuals, GLP-1 RA use was reported to increase the risk of gallbladder stones or biliary tract disease by 37% (RR 1.37 [95% CI 1.231.52])

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