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Description
Within the plaque in that model, the activation of ATP-binding cassette transporter A1 (ABCA1) in macrophages leads to enhanced cholesterol efflux, which prevents foam cell development [24]

EASL-EASD-EASO clinical practice guidelines on the management of metabolic dys-function-associated steatotic liver disease (MASLD)

Among 47 cases with patients with confirmed MCAS, many of whom had not responded adequately to prior therapies, the case series found that 89% demonstrated clinical benefit with GLP-1RAs across a broad range of symptoms

MASH Treatment
The implications of centrally produced, neuromodulatory GLP-1 in the context of GLP-1RAs are uncertain, as the degree to which signals from pre-proglucagon neurons/endogenous GLP-1 system and GLP-1RA activity converge on shared downstream targets is unclear 6 and may in fact occur independently 7

doi: 10.1001/jama.2015.9676 18 Pi-SunyerXAstrupAFujiokaKGreenwayFHalpernAKrempfMet al
