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GLP-1 effects on the hypothalamic pituitary adrenal (HPA) axis Neurons of the NTS are important in the regulation of the hypothalamus-pituitary-adrenal (HPA) axis in response to stress [811], and evidence indicates that brain GLP-1R signaling plays an integral role in the acute CNS response to stress and aversive stimuli [811]
NNC0090-2746 and tirzepatide also display unique agonism properties at their target receptors (108)
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These central effects complement peripheral mechanisms and contribute to the overall gastric motility changes observed with GLP-1 RA therapy [16]
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