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Neither path is inherently wrong

For serious adverse events, the incidence of adverse effects was highest with liraglutide 3.0 mg, followed by liraglutide 1.8 mg, semaglutide 2.4 mg, and semaglutide 1.0 mg

Jama, 2022

As individuals lose weight, their overall energy expenditure decreases because they have less body mass

Hypoglycemia rates were similar across GLP-1 RA treatment groups, as shown in Table 4, and were primarily seen in patients treated with concomitant sulfonylurea (SU) therapy

While some observational data and post-hoc analyses of clinical trials have reported reductions in serum uric acid among patients treated with GLP-1 agonists, these findings have not been consistently replicated across all studies