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For diabetes management, HbA1c reductions typically range from 5-15 mmol/mol (0.5-1.5%) depending on the specific medication and dose, though targets should be individualised based on your circumstances as per NICE guidance

For obesity, orlistat and naltrexone-bupropion (Mysimba) are available but generally less effective than GLP-1 receptor agonists

recently analysed a cohort of 3737 patients with IBD and T2DM, demonstrating that the use of GLP-1RAs was associated with a 26% reduction in the risk of composite IBD outcomes, defined as steroid dependence, the initiation of advanced IBD therapy, hospitalization, surgery, or death (aHR: 0.74, 95% CI: 0.620.89) [32]

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Semaglutide GLP-1 for medical weight loss can be obtained through a prescription from a licensed healthcare provider, often at specialized weight loss clinics, endocrinology practices, or telemedicine services