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If matched one-to-one for dosage, the differences in A1C reduction may not be so stark

The AWARD trials demonstrated preservation of kidney function in patients with type 2 diabetes, adding another dimension to its value beyond pure weight loss

Some researchers report mild headaches during the first week at this dose

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The SELECT trial demonstrated that semaglutide 2.4 mg reduced major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) by 20% in adults with overweight or obesity and established heart disease (Lincoff et al., SELECT trial, New England Journal of Medicine , 2023)