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Retatrutide is the only compound that attacks the energy balance equation from both sides: reducing appetite through GLP-1 and GIP activity, while simultaneously increasing energy expenditure and fat oxidation through glucagon receptor activation

GLP-1 vs GLP-1/GIP What Is the Difference

This article will focus on the NICE-approved indication of tirzepatide for glucose lowering in people with type 2 diabetes

J Pain, 14:1289-1303

Working with a knowledgeable healthcare provider who can guide you through the options, monitor your progress, and adjust treatment as needed is essential for success

The hypothalamus (a focus of this review) is a primary downstream target of peripherally administered GLP1 receptor agonists or hindbrain GLP1 neurons (Gabery et al., 2020