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Liraglutide improved learning and memory performance, attenuated hyperphosphorylation of tau as well as NFs, and prevented neurodegeneration via improving JNK and ERK signaling in brain of 3Tg mice (232)

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With regard to safety concerns, the most prevalent adverse effects associated with GLP-1 RAs are gastrointestinal, such as bloating, dyspepsia, nausea, vomiting, diarrhea and constipation (107)

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In addition, patients may encounter emotional challenges, such as disappointment or frustration, upon discontinuing weight loss medications and subsequently regaining previously lost weight