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In addition, further subgroup analyses for different ages and ADR also yielded negative results (Additional file 1: Fig S56)

Incretin-based antidiabetic therapies, such as glucagon-like peptide-1 receptor agonists (GLP-1RAs), may offer benefits for individuals at risk of neurodegeneration due to their central effects on appetite and satiety regulation via the hypothalamus (Correia et al., 2012)

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