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R3TA provides a single pharmacological tool for studying the combined signalling consequences of simultaneous tri-receptor activation Pancreatic beta cell and insulin secretion models GLP-1 and GIP are the primary incretin hormones

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We next used membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) to cleave the ectodomain of the IR in BMECs to construct a model of cells lacking the ectodomain of IR 24

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