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Three-day intervals showed liraglutide plateaued by Day 4, while combination continued loss to normal range by Day 9, with minimal further loss thereafter (Fig

Although clinicians widely recognize obesity as a modifiable risk factor, achieving and sustaining meaningful weight loss remains a complex challenge in the clinical setting

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[16] In some cases, switching to an alternative agent with different pharmacokinetic properties or discontinuing therapy may be necessary if symptoms significantly impair quality of life or pose health risks

A potential underlying mechanism was described by Cohn et al

Oral semaglutide (Rybelsus) exists but is lower efficacy and approved only for type 2 diabetes