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The SURMOUNT trials showed continued improvement in depression scores through week 72

Once the triggering stressor stabilizes, meaning weight loss slows and nutritional status is optimized, hair follicles resume their normal growth cycle

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GLP-1 medications work by mimicking the action of naturally occurring GLP-1, an incretin hormone released by the intestines in response to food intake

When MPP+ enters cells, it inhibits mitochondrial complex I enzyme and NADHubiquinone oxidoreductase, causing ROS formation and mitochondrial electron leakage (47)

Circulation 145(1):4560 Sarma S, Stoller D, Hendrix J, Howden E, Lawley J, Livingston S, Adams-Huet B, Holmes C, Goldstein DS, Levine BD (2020) Mechanisms of chronotropic incompetence in heart failure with preserved ejection fraction