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PKA-mediated induction of IRS-2 expression also promotes -cell growth in response to GLP-1, 53,62 and PKA mediates the action of GLP-1 to promote translocation of transcription factor PDX-1 to the nucleus, thereby enhancing the differentiated state of -cells

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Conformational changes in the transmembrane domain result in a sharp kink in the middle of transmembrane helix 6, which pivots its intracellular half outward to accommodate the 5-helix of the Ras-like domain of G s

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46 Higher doses are more likely to provoke these adverse symptoms, indicating a dose-dependent relationship