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There are supportive clinical trials in T2DM patients of GLP-1 agonist mediated reduction in plaque burden, size and composition [62]

Moreover, even when prescribed, Hispanic and non-Hispanic Black individuals are more likely to report cost-prohibitive access barriers to diabetes medications, increasing risk in these populations for diabetes-related complications and mortality.[85] As future research aims to comprehensively assess the full scope of GLP-1RAs benefits and risks, it is imperative that such studies include the populations with the greatest potential for benefit and explore strategies to mitigate disparities in post-marketing access to these therapies.[86] CONCLUSIONS Since their introduction two decades ago, GLP-1RAs have expanded from glycemic control to treat a variety of conditions in individuals without diabetes, including weight management, cardiovascular risk reduction, and obstructive sleep apnea