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I remain skeptical - every study of low calorie diets and bariatric surgery showed negative effects on bone density and/or markers

These findings were confirmed in high-fat, high-cholesterol (HFHC) dietfed mice with functional LDL receptor deficiency induced by viral expression of proprotein convertase subtilisin/kexin type 9adeno-associated virus (PCSK9-AAV), in which daily administration of semaglutide for 18 weeks reduced aortic plaque area (11)

GLP-1 has one of the most extensive published research bases of any peptide hormone in modern biomedical science, with thousands of peer-reviewed studies spanning its discovery, physiology, receptor pharmacology, and the entire GLP-1RA drug class built upon it

Pacing Clin Electrophysiol 2010;33:13921406

In August 2025, Eli Lilly (US) announced a collaboration with a leading technology firm to integrate artificial intelligence into its drug development processes

Salvi P, Kosta S, Fobi M, et al