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In considering which interventions under study for preventing and/or treating AD/ADRD show promise, the committee identified the following three categories of interventions based on different endpoints of relevance

[60] History and clinical trials [edit] In the 1970s, Jens Juul Holst and Joel Habener began research on GLP-1, initially in relation to duodenal ulcer disease

The efficacy of Semaglutide for seniors has been demonstrated in multiple studies, with participants experiencing an average weight loss of 10-15% of their body weight

Furthermore, tirzepatide has shown longer titration periods in clinical practice, delaying attainment of full maintenance doses and potentially dampening early cardiovascular benefits 28

Sources: Martnez-Gmez, Mario G., and Brandon M

The reduced payoff makes even the most crave-inducing unhealthy foods less desirable, and as a direct result, makes a person less likely to want to indulge in foods that would contribute to weight gain