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We have more options now, but two of the four new drugs on the market (Qsymia and Contrave) have struggled for a lack of commercial success

Likewise, it is important to understand whether different patterns of inflammation cause specific clinical subtypes that may require personalized therapeutic intervention

The upcoming SURMOUNT-MAINTAIN trial, expected to report results around mid-2026, will specifically compare the 5 mg maintenance dose against higher doses for weight maintenance after initial loss

TRAILBLAZER-ALZ 3 (NCT05026866) is a placebo-controlled phase 3 prevention trial that was started in August 2021

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Escalation pauses or steps back if side effects become troublesome