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Zepbound was FDA-approved in 2023 for long-term weight management in adults with obesity (with a body mass index of 30 or higher) and overweight (with a body mass index of 27 or higher) with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol

Yes, diphenhydramine (Benadryl) can be taken before injection to reduce reactions

Development Status, Safety, and Future Outlook Mazdutide is currently in clinical development and has not yet received regulatory approval for general use

The confusion around dose timing is understandable

doi: 10.1111/dom.14496 [DOI] [PubMed] [Google Scholar] 46

Doctors generally do not advise taking two doses too close together because it increases the risk of side effects