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Retrieved 3 March 2023

Interestingly, treatment of mouse cardiomyocytes with GLP-1 936 amide (a GLP-1 degradation product in vivo) resulted in Akt activation, extracellular regulated kinase (ERK) phosphorylation, and reduced apoptosis induced by hypoxia or hydrogen peroxide stress, implying an unconventional action of GLP-1 (Ban et al., 2010)

Additionally, weight loss reduces gallbladder motilitythe organ contracts less frequently and less completely, allowing bile stasis that facilitates stone development

Patients experiencing cold sensitivity whilst on GLP-1 therapy can implement several practical strategies to maintain comfort without discontinuing beneficial treatment

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Although some degree of lean mass decline is physiologically expected, its clinical relevance may vary according to age, baseline muscle reserve, physical activity, nutritional intake, and endocrine status