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While other GLP-1R agonists have shown promising outcomes in mitigating cancer progression, the association between some GLP-1R agonists and an increased risk of cancer remains a topic requiring more profound investigation

Glucose-dependent insulinotropic polypeptide (GIP) is an intestinal hormone that potentiates glucose-induced insulin secretion in the postprandial state

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Key milestones highlighted in this timeline: 1999 Orlistat (Xenical) The first long-term FDA-approved anti-obesity medication of the modern era

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These findings align with prior randomized trials and meta-analyses suggesting class-level cardiovascular benefit