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[Source: Fierce Pharma ] January 2025 The FDA fast-tracked tirzepatide for cardiovascular risk reduction in obesity patients, following landmark trial results showing significant benefit beyond weight loss

While preclinical studies support this hypothesis, robust clinical evidence remains limited

0.7% divided by 2.3% = 30% - is translated as a 30% relative difference when comparing one group to another

111 Reduced production of pro-inflammatory cytokines, blocked NF-B signaling, and increased regulatory T-cell activity are some of the mechanisms through which GLP-1RA protects against intestinal inflammation in early-stage IBD models 112 (Figure 1)
