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For planned comparisons against a single treatment of interest, Dunnetts test was applied using the relevant reference group (PG-102 for preclinical experiments, placebo for clinical datasets)

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doi: 10.1016/j.cmet.2018.03.001 178 JonesBBloomSRBuenaventuraTTomasARutterGA

Exendin-4 may affect -cell number by stimulating cellular proliferation 21, 22