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Using these antibodies, immunohistochemical studies in tissues from humans and non-human primates confirmed the presence of GLP-1R in the pancreas with broad expression in the -cells, weaker abundance in the acinar cells, and no expression in the duct cells [392]

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Consequently, dual GLP-1/glucagon agonists survodutide, and triple GLP-1/GIP/glucagon agonists retatrutide are not spared gastrointestinal adverse events, as glucagon related pro-emetic signaling may offset any potential tolerability benefits from GIP agonism ( The contribution of amylin-based therapies to gastrointestinal adverse events remains less clear