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Because the upper limit of the two-sided 95% CI for the estimated differences was below 0 kg, superiority of SEM 0.5 mg or SEM 1 mg versus placebo in change in body weight was demonstrated

GLP-1 medications are prescription-only and require an in-person evaluation to ensure safety and fit

doi: 10.1038/s41467-024-47799-z
Nausea, vomiting, constipation, and diarrhea occur more frequently at 2.4 mg than at lower doses, though many individuals tolerate the maximum dose well