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Specific trials about the impact of GLP-1 RAs treatment on the risk of HCC incidence or recurrence are currently lacking

In a 2-year CV outcomes trial with semaglutide injection involving patients with type 2 diabetes mellitus and high CV risk, diabetic retinopathy complications (which was a 4-component adjudicated endpoint) occurred in patients treated with semaglutide injection (3%) compared to placebo (1.8%)

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GLP-1 receptor agonists: available evidence does not support a link with suicidal and self-injurious thoughts and actions

Implement supportive care measures if needed Lifestyle strategies are powerful during this phase