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Inconsistent use of some GLP-1RAs for weight loss may significantly lessen their effectiveness, according to a new preclinical study in mice.

This occurs due to overall weight loss and preferential mobilization of peripheral fat stores

The dynamics of this first wave of offpatent entrants will be shaped not just by the cost of development, but also by regulatory classification, privatemarket affordability, and innovators ability to segment the market with second brands and nextgeneration therapies

It represents a fundamental shift in how obesity should be treated in clinical practice

and increased insulin early AUC and C-peptide total and early AUCs

Among T2DM patients on antipsychotics, more patients in the combination group achieved weight loss5% within the study period compared to metformin monotherapy