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Doses up to 60mg/kg per day produced no observable toxicity

However, as with any supplement or treatment, there's potential for side effects, especially when B12 is given in very high doses

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Salivary pH while dissolving vitamin C-containing tablets

Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis

doi: 10.1038/ncomms4633