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However, modern advancements in supplement formulation have significantly improved the bioavailability of oral B12, making it a more effective option than ever before

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This is because active folate (methylfolate) is required for B12-dependent reactions, and MTHFR variants can reduce folate availability
[DOI] [PubMed] [Google Scholar] 210.Yang D, Li Y, Xing L, Tan Y, Sun J, Zeng B, et al
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