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Description
Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy
Challenges include patient adherence, nutritional deficiencies, and the need for individualized dietary planning
Lactate enhances NMNAT1 lactylation to sustain nuclear NAD+ salvage pathway and promote survival of pancreatic adenocarcinoma cells under glucose-deprived conditions
Nov 2015;70(11):765-9
doi: 10.1038/sj.ijir.3900876
The patients are often young and left with paralysis, spasticity and loss of sphincter control
