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Since the activation of these pathways sometimes produces opposite effects, the concurrent action on two or more of them could result in a complementary and synergistic effect [154]

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Second-generation long-acting molecules (liraglutide, dulaglutide, and semaglutide) introduced enhanced receptor engagement profiles and extended half-lives, enabling once-weekly administration while significantly improving glycemic control and weight reduction outcomes [8,9,10]

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Interestingly, the lifespan of mog-3(-) worms showed no significant change after mating (Fig
