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CVS Caremark announced on May 1, 2025 that AOM tirzepatide (sold as Zepbound) would be removed from its standard preferred formulary effective July 1, 2025 ( 2 , 3 )

Scientists at the 23andMe Research Institute published a study in Nature that has identified genetic variants associated with weight loss and side effects among those who have taken GLP-1 medications

Unfortunately, GLP-1 treatment rarely arrives from the prescriber with these questions attached

Biochem Pharmacol 110111:2536 Mikami D, Kimura H, Kamiyama K, Torii K, Kasuno K, Takahashi N et al (2014) Telmisartan activates endogenous peroxisome proliferator-activated receptor- and may have anti-fibrotic effects in human mesangial cells

Consult your prescribing information or healthcare provider for your specific medications flexibility

Who Qualifies GLP-1 medications for weight management are appropriate for adults who meet the following criteria: BMI of 30 or higher (obesity), or BMI of 27 or higher with at least one weight-related condition (high blood pressure, type 2 diabetes, high cholesterol, sleep apnea) Who should not take GLP-1 medications: Personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) History of pancreatitis Severe gastrointestinal disease (gastroparesis, inflammatory bowel disease) Pregnancy or planning to become pregnant Known hypersensitivity to semaglutide, tirzepatide, or any component of the formulation Your physician will review your full medical history, screen for contraindications, and assess your relationship with food and body image before prescribing